Revealing factors determining immunodominant responses against dominant epitopes
نویسندگان
چکیده
منابع مشابه
Immune responses against multiple epitopes.
The current understanding of antigenic escape dynamics is based on models with single epitopes. The usual idea is that a mutation which enables a pathogen (virus, bacteria, etc) to escape from a given immune response confers a selective advantage. The "escape mutant" may then increase in abundance until it induces a new specific response against itself. In this paper a new picture is developed,...
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We extend well-known mathematical models of viral infection to examine the response of cytotoxic T lymphocytes (CTL) to both conserved and variable viral epitopes. Because most viruses are subject to error-prone reproduction, CTL recognition may be faced with highly variable epitopes, while other CTL epitopes may remain conserved across viral strains. In this paper we examine the steady state c...
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ژورنال
عنوان ژورنال: Immunogenetics
سال: 2019
ISSN: 0093-7711,1432-1211
DOI: 10.1007/s00251-019-01134-9